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Ming-Hon Hou Publications
Academic Publications (期刊論文) (* Corresponding Author)
2025
2026

  • Shun-Ching Wang, Chang-Chih Hsieh, Tzu-Chun Yuan, Shan-Meng Lin, Chia-Wei Chen, Chih-Chun Chang, Shih-Chun Huang, En-Chi Wang, Yu-Jhen Huang, Ming-Hsi Chiang, Yih-Chern Horng*, and Ming-Hon Hou* (April 2026) Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription, Nucleic Acids Research, Accepted.

2025
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2021
2021
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2024
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2013

  • Mikael Cristofer Sitinjak, Jui-Kai Chen, Fang-Lin Liu , Ming-Hon Hou, Shan-Meng Lin, Hung-Jen Liu, Chi-Young Wang (Aug 2024) Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV), Virus Research, Volume349, 199458,  (https://doi.org/10.1016/j.virusres. 2024.199458) (IF=2.5, Rank=43.9%=18/41,Virology)   

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2018

  • Wesley Tien Chiang, Yao-Kai Chang, Wei-Han Hui, Shu-Wei Chang, Chen-Yi Liao, Yi-Chuan Chang, Chun-Jung Chen, Wei-Chen Wang, Chien-Chen Lai, Chun-Hsiung Wang, Siou-Ying Luo, Ya-Ping Huang, Shan-Ho Chou, Tzyy-Leng Horng, Ming-Hon Hou, Stephen P. Muench, Ren-Shiang Chen, Ming-Daw Tsai* and Nien-Jen Hu*(May 2024) Structural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB​, Nature Communications, 15, Article number: 3850 (2024) (IF=16.6, Rank=8.2% = 6/73,MULTIDISCIPLINARY SCIENCES )

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會議演講 (Invited speeches)
Month, Year
Title
Conference/Place
November, 2022
Structural Biology in Drug Discovery against Life-threatening Diseases
In: 2022 Engineering Bioscience Symposium Challenges & Opportunities in Post-Pandemic Era, National Yang Ming Chiao Tung University, Taiwan (November 18, 2022)
October, 2022
Structural Biology in Drug Discovery against Life-threatening Diseases
In: Lectures of Microbiology & Immunology of National Cheng Kung University, Taiwan (October 3, 2022)
August, 2022
Targeting mismatches with small molecules induces unusual structural features in disease-related DNA duplexes with therapeutic applications.
In: INDIA-EMBO Lecture Course 2022, RCB Faridabad, India (August 18, 2022, Remote talk)
June, 2022
Nucleocapsid capsid protein is a potential target for drug discovery against coronavirus
In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan (June 25, 2022)
March, 2022
Structural basis for targeting mismatches with small molecules induces unusual structure features in disease-related DNA duplexes
In: 化學年會2022, National Taiwan Normal University, Taiwan (March 12, 2022)
December, 2021
Structural biology in drug discovery against life-threating disease
In: Lectures of NTU Chemistry, National Taiwan University, Taiwan (December 2, 2021)
December, 2020
Drug Discovery Platform by Targeting Non-native Protein-Protein Interaction
In: UCDS-NCHU/ENABLE/IDCSA Joint Symposium at National Chung Hsing University Taiwan (December 14, 2020)
December, 2020
Structural biology in drug discovery against CoV disease and cancer
In: National Tsing Hua University Taiwan (December 10, 2020)
November, 2020
Targeting Non-native Protein–protein Interactions of Nucleocapsid Proteins for Drug Discovery Against Coronavirus
In: The NSRRC 2020 Annual Users’ Meeting & Workshops (November 10, 2020)
July, 2020
Development of novel antiviral and anticancer agents: from bench to clinical research
In: 2020 亞洲生技大會BIO Asia - Taiwan (July 23, 2020)
February, 2019
Structure-based virtual screening and experimental validation of novel human coronavirus nucleocapsid protein anti-viral inhibitors
In: Structure Assisted Development of Novel Therapeutics 2019; 2019 Feb 12-16. Faridabad, India (February 15, 2019)
October, 2018
The action of DNA-binding ligands with unusual DNA structures: implications for therapy and diagnosis of diseases
In: 第十二屆會員代表大會暨2018年全國學術會議; 2018 Oct 25-28. Chongqing, China (October 26, 2018)
研討會論文 (Conference and Seminar poster presentations)
Year
Conference/Seminar name
Authors
Title
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Shun-Ching Wang and Ming-Hon Hou*
Structural basis of Myotonic Dystrophy type 1 CUG repeat RNA crystal reveal multiple water mediated U-U mismatches
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Shih-Chun Huang and Ming-Hon Hou*
Structure based study of the binding mechanism of bis-intercalator to DNA duplex
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle and Ming-Hon Hou*
Targeting DNA mismatches by two distinct intercalators exhibit synergistic effect against mismatch repair deficient cancers
2021
In: Chemistry National Meeting,2021, National Central University, Taiwan
Yu-Zhu Huang and Ming-Hon Hou*
Development of triaminotriazine-acridine conjugate (Z1) as a probe to detect cancer-related mismatch in solution
2019
In: Structure Assisted Development of Novel Therapeutics 2019; 2019 Feb 12-16. Faridabad, India.
Roshan Satange and Ming-Hon Hou *
Structural heterogeneity in DNA duplex with symmetric G:G mismatches upon CoII(Chromomycin A3)2 and Actinomycin D binding
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Jing-Yi Zeng, Tzu-Jung Huang and Ming-Hon Hou*
The terminal base pairs determine the conformation of DNA duplex with G:T mismatch. pp.117 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Ching-Ming Chien, Jia-Ning Hsu and Ming-Hon Hou*
Homology Modeling and Crystallization of N-terminal domain of Porcine Epidemic Diarrhea Virus Nucleocapsid Protein. pp.90 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Pei-Ching Wu, Shu-Ling Tzeng, Chung-ke Chang, Ya-Fen Kao, Michael J. Waring and Ming-Hon Hou*
Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex. pp.106 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Hsiang-Ti Huang and Ming-Hon Hou*
Structural basis for the binding of Echinomycin to DNA duplex containing I:C mismatch. pp.91 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Yun-Jean Lin and Ming-Hon Hou*
Structural study of the specific interactions between echinomycin and methylated DNA containing the CCG motif. pp.103 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Roshan Satange and Ming-Hon Hou*
Synergistic intercalation of echinomycin and actinomycin D to DNA duplex with T:T mismatch causes single strand deformation. pp.104 (Poster)
2017
In: the 31st Annual Symposium of The Protein Society, 2017 July 24–27, Montreal, Canada.
Hou, MH; Hsu, CN
Structural basis for identification of the interface of the N-terminal domain of CoV N protein dimer as a target for drug development. pp. 196 (Abstract POS501) (Dec 2017)
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