藥 物 設 計 及 化 學 生 物 核 心 實 驗 室
Lab News
July 2024 - Our new study on targeting DNA-DNA junctions has been accepted for publication in the Nucleic Acids Research. Another successful collaboration. Congratulations to Prof. Ming-Hon Hou, Prof. Yih-Chern Horng and the team!
'Targeting DNA junction sites by bis-intercalators induces topological
changes with potent antitumor effects'
June 2024 - Our new study on a water-mediated noncanonical base pair formation induced by non-CpG methylation that provides novel insights into DNA conformation during epigenetic regulation has been accepted for publication in the Nucleic Acids Research. Another successful collaboration. Congratulations to Prof. Ming-Hon Hou, Prof. Stephen Neidle, Prof. Shan-Ho Chou, Dr. Chung-ke Chang, Dr. Chi-Fon Chang, Dr. Shan-Meng Lin and the team!
'Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation'
May 2024 - Congratulations Mr. Sankar Panthi for winning the Silver Medal Award in the category of Personal Experience Article of the 2024 NCHU Ambassador (2024 Winter Vacation).
January 2024 - Our new study on targeting protein–protein interaction interfaces with anti-viral N-protein inhibitor in SARS-CoV-2 has been accepted for publication in the Biophysical Journal. Another successful research collaboration. Congratulations to Prof. Hou, Prof. Kehn-Hall, Prof. Luo, Prof. Wu, Dr. Lin and team!
'Targeting protein–protein interaction interfaces with anti-viral N-protein inhibitor in SARS-CoV-2'
June 2023 - Our PhD students Shun-Ching Wang and Chih-Chun Chang won the Third place and the Honorable Mention Award at NCHU Scientific Poster Competition 2023. Congratulations both of you!
May 2023 - Our new study about myotonic dystrophy type 1 causing CUG RNA repeat has been accepted to publish in the Journal of Biological Chemistry. Congratulations Prof. Ming-Hon Hou, Prof. Jhih-Wei Chu (National Chiao Tung University) and the team!
"Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1"
May 2023 - Our research paper on AI based machine learning model has been published in the journal Frontiers in Medicine. Congratulations Prof. Ming-Hon Hou, Dr. Kuo-Yang Huang and the entire team!
"Developing a machine-learning model for real-time prediction of successful extubation in mechanically ventilated patients using time-series ventilator-derived parameters"
February 2023 - Our new research paper has been accepted for publication in the journal Nucleic Acids Research. A collaborative effort between National Chung Hsing University (Prof. Ming-Hon Hou and his team) and University College London, UK (Prof. Stephen Neidle). Congratulations!
"Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects"
February 2023 - Congratulations Dr. Roshan Satange for winning 2022 Postdoctoral Fellow Academic Research Award from the National Science and Technology Council (NSTC).
Dr. Roshan is one of the forty awardees from all academic research fields. He received this award for his research on "Staggered intercalation of DNA duplexes with base- pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism" published in Nucleic Acids Research, Volume 50, Issue 15, 26 August 2022, Pages 8867-8881, https://doi.org/10.1093/nar/gkac629
Congratulations!
December 2022 - Our recent research publication in NAR is highlighted on NSRRC's 'Research Highlights' of this year. Congratulations Prof. Ming-Hon Hou and collaborators!
December 2022 - Professor Ming-Hon Hou and his research team won the 2022 "National Innovation and Excellence Award". Congratulations Prof. Hou and team!
December 2022 - We have been invited to exhibit our research at Healthcare+ Expo Taiwan 2022. Congratulations Prof. Ming-Hon Hou and team!
December 2022 - 生技製藥人才培育計畫-雲端人工智慧藥物開發系統工作坊.
November 2022 - Our research is highlighted on NCHU ARCH 4. Congratulations Prof. Hou and team.
November 2022 - Congratulations Dr. Roshan Satange and Dr. Jhen-Yi Hong for winning the best oral presentation and best poster presentation awards at ISBAB-2022.
August 2022 - Congratulations Dr. Jhen-Yi Hong for Award of Recognition at 28th User Meeting and Workshop, NSRRC, Taiwan.
August 2022 - Congratulations Prof. Ming-Hon Hou for being selected as a national committee member of Crystallographic Committee, Academia Sinica, R.O.C. (Taiwan)
July 2022 - Our new research paper has been accepted for publication in the journal Nucleic Acids Research. A collaborative effort between National Chung Hsing University (Prof. Ming-Hon Hou and his team) and University College London, UK (Prof. Stephen Neidle). Congratulations!
"Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism"
June 2022 - Our PhD students Chih-Chun Chang and Shun-Ching Wang won the Honorable Mention Award at NCHU Scientific Poster Competition 2022. Congratulations both of you!
June 2022 - Prof. Hou has been elected as a council member of Biophysical Society of R.O.C. Congratulations!
June 2022 - Congratulations Dr. Roshan Satange for winning honorable performance of the poster award of ABA.APPA.TBS Joint Congress 2022
May 2022 - Our NAR paper, 'Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction' is featured in the annual report of NSRRC 2021.
May 2021- Our JACS paper, 'Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA' is featured in the annual report of NSRRC 2020.
April 2021- Congratulations Prof. Ming-Hon Hou for wining Outstanding Research Award 2020 from the Ministry of Science and Technology (MOST).
December 2020- Congratulations to Prof. Ming-Hon Hou and his team for winning the 17th National innovation Award in the Academic Research Category.
July 2020- 中興大學攜手美國與華安醫學開發抗新冠病毒藥物於亞洲生技大展發表最新進展
中興大學「基因體生物資訊研究所」侯明宏教授7/23於2020亞洲生技大展進行相關發表。圖/國際產學聯盟提供
科技部吳政忠部長、生科司陳鴻震司長和產學司邱求慧司長親臨團隊攤位聽取侯明宏教授解說。圖/國際產學聯盟提供
中興大學國際產學聯盟成員和研究團隊成員合照，侯明宏教授(右三)，黃澤富營運長(右二)。圖/國際產學聯盟提供
June 2020- Congratulations Roshan for winning the Third Place in the Scientific Paper Competition organized by the College of Sciences, National Chung Hsing University on June 30, 2020.
March 2020- Congratulations Prof. Ming-Hon Hou, Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-ke Chang, Ching-Ming Chien, Yong-Sheng Wang, Hung-Yi Wu, U-Ser Jeng and Kylene Kehn-Hall for publishing the research article in the Journal of Medicinal Chemistry.
Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design
October 2019- Congratulations Prof. Ming-Hon Hou, Jyung-Hurng Liu, Jun-Yi Yang, Duen-Wei Hsu, Yi-Hua Lai , Yun-Pei Li and Yi-Rung Tsai for publishing the paper in International Journal of Molecular Sciences.
Crystal Structure-Based Exploration of Arginine-Containing Peptide Binding in the ADP-Ribosyltransferase Domain of the Type III Effector XopAI Protein
July 2019- Congratulations Prof. Ming-Hon Hou, Roshan Satange, Chien-Ying Chuang and Stephen Neidle for publishing the paper in Nucleic Acids Research.
Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation
February 2019- Roshan wins the outstanding poster presentation award at an international conference on the Structure Assisted Development of Novel Therapeutics 2019 organized by Regional Centre for Biotechnology, Faridabad, India during 12-16 February 2019.
Structural heterogeneity in DNA duplex with symmetric G:G mismatches upon CoII(Chromomycin A3)2 and Actinomycin D binding
June 2018- Congratulations Prof. Ming-Hon Hou, Roshan Satange and Chung-ke Chang for publishing the review article in Nucleic Acids Research.
A survey of recent unusual high-resolution DNA structures provoked by mismatches,
May 2018- Congratulations Prof. Ming-Hon Hou, Pei-Ching Wu, Chung-ke Chang and Ya-Fen Kao for publishing the paper in Nucleic Acids Research.
Cooperative recognition of T:T mismatch by echinomycin causes structural distortions
March 2018- Welcome Dr. Ching-Ming Chien to join our lab as Post-Doctoral Research fellow.
March 2018- Congratulations Prof. Ming-hon Hou, Roshan Satange and Chung-ke Chang for publishing the new chapter in the book DNA-targeting Molecules as Therapeutic Agents by Royal Society of Chemistry (RSC).
"Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases."
December 2017- Congratulations YUN-JEAN,LIN for her successful talk on " 考研究所不可不知道的事" held at DAYEH UNIVERSITY, Taiwan (大葉大學 ) on December 11, 2017.
September 2017- Welcome to Miss. Jonna Schulz-Ehlbeck to join our lab as an intern student.
August 2017- Congratulations Tzu-Jung, Huang (Gina) for her graduation. May this be the beginning of a successful journey.
August 2017- Congratulations, Dr. Ming-Hon Hou, Tze-Yun Huang and Ya-Fen Kao for accepting their manuscript in PNAS.
"Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion."