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2021
Academic Publications (期刊論文) (* Corresponding Author)
Ming-Hon Hou Publications
2024
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2021

  • Mikael Cristofer Sitinjak, Jui-Kai Chen, Fang-Lin Liu , Ming-Hon Hou, Shan-Meng Lin, Hung-Jen Liu, Chi-Young Wang (Aug 2024) Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV), Virus Research, Volume349, 199458,  (https://doi.org/10.1016/j.virusres. 2024.199458) (IF=2.5, Rank=43.9%=18/41,Virology)   

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2013

  • Wesley Tien Chiang, Yao-Kai Chang, Wei-Han Hui, Shu-Wei Chang, Chen-Yi Liao, Yi-Chuan Chang, Chun-Jung Chen, Wei-Chen Wang, Chien-Chen Lai, Chun-Hsiung Wang, Siou-Ying Luo, Ya-Ping Huang, Shan-Ho Chou, Tzyy-Leng Horng, Ming-Hon Hou, Stephen P. Muench, Ren-Shiang Chen, Ming-Daw Tsai* and Nien-Jen Hu*(May 2024) Structural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB​, Nature Communications, 15, Article number: 3850 (2024) (IF=16.6, Rank=8.2% = 6/73,MULTIDISCIPLINARY SCIENCES )

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2021
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2018
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2016
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2011-2001

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會議演講 (Invited speeches)
Month, Year
Title
Conference/Place
November, 2023
Structural Biology in Drug Discovery against Life-threatening Diseases
In: Department of Biological Sciences, National Sun Yat-sen University, Taiwan.(30 November 2023)
December, 2023
Structural Biology in Drug Discovery against Life-threatening Diseases
In: Shih Chien University, Taiwan. (25 December 2023. )
March, 2024
Structural Basis of Water-Mediated Hoogsteen Base-Pair Formation in Non-CpG Methylation
In: 2024 Chemistry National Meeting, Tamkang University, Taiwan.(31 March 2024)
April, 2024
Structural Biology in Drug Discovery against Life-threatening Diseases
In: Department of Chemistry and Biochemistry, National Chung Cheng University(23 April 2024)
May, 2024
Structural Biology in Drug Discovery against Life-threatening Diseases
In: College of Medicine, National Taiwan University, Taiwan. (1 May 2024)
November 2023
Targeting protein-protein interaction interfaces with Anti-viral N protein inhibitor in SARS-CoV-2
In: The 17th International Symposium on Biocatalysis and Agricultural Biotechnology; November 8-10, 2023, National Chung Hsing University, Taichung, Taiwan.
September 2023
Research Life Experience Sharing
In: National Sun Yat-Sen University, Kaohsiung, Taiwan (September 15, 2023)
August 2023
Synergistic binding of two distinct antibiotic intercalators to mismatch sites and their applications in cancer therapy
In: National Tsing Hua University; Hsinchu, Taiwan (August 31, 2023)
July 2023
Targeting trinucleotide repeats using DNA binding small molecules with conformational polymorphism
In: Department of Chemistry, National Taiwan University, Taiwan (July 12, 2023)
May, 2023
Structural Biology in Drug Discovery against Life-threatening Diseases
In: Lectures of NTHU Chemistry, National Tsing Hua University, Taiwan (May 10, 2023)
November, 2022
Structural Biology in Drug Discovery against Life-threatening Diseases
In: 2022 Engineering Bioscience Symposium Challenges & Opportunities in Post-Pandemic Era, National Yang Ming Chiao Tung University, Taiwan (November 18, 2022)
October, 2022
Structural Biology in Drug Discovery against Life-threatening Diseases
In: Lectures of Microbiology & Immunology of National Cheng Kung University, Taiwan (October 3, 2022)
August, 2022
Targeting mismatches with small molecules induces unusual structural features in disease-related DNA duplexes with therapeutic applications.
In: INDIA-EMBO Lecture Course 2022, RCB Faridabad, India (August 18, 2022, Remote talk)
June, 2022
Nucleocapsid capsid protein is a potential target for drug discovery against coronavirus
In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan (June 25, 2022)
March, 2022
Structural basis for targeting mismatches with small molecules induces unusual structure features in disease-related DNA duplexes
In: 化學年會2022, National Taiwan Normal University, Taiwan (March 12, 2022)
December, 2021
Structural biology in drug discovery against life-threating disease
In: Lectures of NTU Chemistry, National Taiwan University, Taiwan (December 2, 2021)
December, 2020
Drug Discovery Platform by Targeting Non-native Protein-Protein Interaction
In: UCDS-NCHU/ENABLE/IDCSA Joint Symposium at National Chung Hsing University Taiwan (December 14, 2020)
December, 2020
Structural biology in drug discovery against CoV disease and cancer
In: National Tsing Hua University Taiwan (December 10, 2020)
November, 2020
Targeting Non-native Protein–protein Interactions of Nucleocapsid Proteins for Drug Discovery Against Coronavirus
In: The NSRRC 2020 Annual Users’ Meeting & Workshops (November 10, 2020)
July, 2020
Development of novel antiviral and anticancer agents: from bench to clinical research
In: 2020 亞洲生技大會BIO Asia - Taiwan (July 23, 2020)
February, 2019
Structure-based virtual screening and experimental validation of novel human coronavirus nucleocapsid protein anti-viral inhibitors
In: Structure Assisted Development of Novel Therapeutics 2019; 2019 Feb 12-16. Faridabad, India (February 15, 2019)
October, 2018
The action of DNA-binding ligands with unusual DNA structures: implications for therapy and diagnosis of diseases
In: 第十二屆會員代表大會暨2018年全國學術會議; 2018 Oct 25-28. Chongqing, China (October 26, 2018)
September, 2018
Recognition of Single-base Mismatch by Echinomycin Raises the Possibility of Repurposing the Drug Against MMR-deficient Cancers
In: 24th Users' Meeting & Workshops, NSRRC; 2018 Sep 11-13. Hsinchu, Taiwan (September 11, 2018)
July, 2018
Coronaviral Nucleocapsid Protein is a Potential Target for Drug Development
In: BIT's 7th Annual World Congress of Infectious Diseases (WCID-2018); 2018 July 11-14; Bangkok, Thailand (July 12, 2018)
May, 2018
Binding of small molecules to trinucleotide DNA repeats associated with fragile X syndrome
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan.
研討會論文 (Conference and Seminar poster presentations)
Year
Conference/Seminar name
Authors
Title
2023
In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023)
Jia-Rong Tsai, Ming-Hon Hou*
Structural basic and conformational transitions of Actinomycin D-Induced Higher-Order DNA Structures in Mismatched Sequences
2023
In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023)
Yen-Yi Lee, Mig-Hon Hou*
Probing the binding mechanism of Actinomycin D and Echinomycin to bulged DNA
2023
In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023)
Roshani Bele, Pi-Chung Wang*, Ming-Hon Hou*
Performance improvement of packet classification algorithm by using Decision trees: Implication for biomedical data management
2023
In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023)
Jia-Ying Chen, Ming-Hon Hou*
Exploring the therapeutic potential of NA compounds and their application in anti-colorectal cancer strategies
2023
In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023)
Shih-Chun Huang, Ming-Hon Hou*
Symmetric and asymmetric bisacridine derivatives inhibit cancer cell proliferation via binding DNA duplexes
2023
In: Chemistry National Meeting, National University of Kaohsiung, Taiwan
Shih-Chun Huang, Ming-Hon Hou*
Structure based study of the binding mechanism of bis-intercalator to DNA duplex
2023
In: Chemistry National Meeting, National University of Kaohsiung, Taiwan
Chia-Yu Chen, Ming-Hon Hou*
Structure-based studies of actinomycin D and Z3 molecules targeting Z-DNA sequence for novel anti-cancer approach
2023
In: Chemistry National Meeting, National University of Kaohsiung, Taiwan
Jia-Rong Tsai, Ming-Hon Hou*
Structural-based study of a Four-Way Junction like DNA structure formation containing a T:T mismatch induced by actinomycin D
2022
In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan
Tsai-Hsuan Han, Chih-Chun Chang and Ming-Hon Hou*
The mechanism study of the clinical DNA intercalator- Doxorubicin targeting DNA duplexes for developing potential cancer therapy
2022
In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan
Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle and Ming-Hon Hou*
Targeting DNA mismatches by two distinct intercalators exhibit synergistic effect against mismatch repair deficient cancers
2022
In: Functional Nucleic Acids INDIA-EMBO Lecture Course 2022, Faridabad, Delhi NCR, India
Shun-Ching Wang and Ming-Hon Hou*
Structural basis of Myotonic Dystrophy type 1 CUG repeat RNA crystal reveal multiple water mediated U-U mismatches (online)
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Jhen-Yi Hong and Ming-Hon Hou*
Targeting the N-terminus domain of the coronavirus nucleocapsid protein induces abnormal oligomerization via allosteric modulation
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Shun-Ching Wang and Ming-Hon Hou*
Structural basis of Myotonic Dystrophy type 1 CUG repeat RNA crystal reveal multiple water mediated U-U mismatches
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Shih-Chun Huang and Ming-Hon Hou*
Structure based study of the binding mechanism of bis-intercalator to DNA duplex
2022
In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan
Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle and Ming-Hon Hou*
Targeting DNA mismatches by two distinct intercalators exhibit synergistic effect against mismatch repair deficient cancers
2021
In: Chemistry National Meeting,2021, National Central University, Taiwan
Yu-Zhu Huang and Ming-Hon Hou*
Development of triaminotriazine-acridine conjugate (Z1) as a probe to detect cancer-related mismatch in solution
2019
In: Structure Assisted Development of Novel Therapeutics 2019; 2019 Feb 12-16. Faridabad, India.
Roshan Satange and Ming-Hon Hou *
Structural heterogeneity in DNA duplex with symmetric G:G mismatches upon CoII(Chromomycin A3)2 and Actinomycin D binding
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Jing-Yi Zeng, Tzu-Jung Huang and Ming-Hon Hou*
The terminal base pairs determine the conformation of DNA duplex with G:T mismatch. pp.117 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Ching-Ming Chien, Jia-Ning Hsu and Ming-Hon Hou*
Homology Modeling and Crystallization of N-terminal domain of Porcine Epidemic Diarrhea Virus Nucleocapsid Protein. pp.90 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Pei-Ching Wu, Shu-Ling Tzeng, Chung-ke Chang, Ya-Fen Kao, Michael J. Waring and Ming-Hon Hou*
Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex. pp.106 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Hsiang-Ti Huang and Ming-Hon Hou*
Structural basis for the binding of Echinomycin to DNA duplex containing I:C mismatch. pp.91 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Yun-Jean Lin and Ming-Hon Hou*
Structural study of the specific interactions between echinomycin and methylated DNA containing the CCG motif. pp.103 (Poster)
2018
In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan
Roshan Satange and Ming-Hon Hou*
Synergistic intercalation of echinomycin and actinomycin D to DNA duplex with T:T mismatch causes single strand deformation. pp.104 (Poster)
2017
In: the 31st Annual Symposium of The Protein Society, 2017 July 24–27, Montreal, Canada.
Hou, MH; Hsu, CN
Structural basis for identification of the interface of the N-terminal domain of CoV N protein dimer as a target for drug development. pp. 196 (Abstract POS501) (Dec 2017)
2011
In: 22nd FAOBMB conference
Hsu CW, Chuang SM and Hou MH *
Comparison of DNA-binding properties and anti proliferative effects for chromomycin A3 dimer chelated with various divalent metal ions
2011
In: The 36th FEBS congress
Hou MH*, Liu CL, Chen IJ and Chou CC
Identification of the N-terminal domain of human coronaviral nucleocapsid protein as a potential antiviral target
2012
In: 17th Joint International Conference of Biophysics and Annual Conference of the Biophysical Society of ROC
Tseng WH, Yuann JM, Lin HY, and Hou MH*
The effects of loop size on Sac7d-hairpin DNA interactions
2012
In: Taiwan Society for Biochemistry and Molecular Biology
Chen YW, and Hou MH*
The binding of the Co(II) complex of dimeric chromomycin A3 to GC sites with flanking G:G mismatches
2012
In: Taiwan Society for Biochemistry and Molecular Biology
Lin YH, Chen CL, Huang HS, and Hou MH*
The study of anthrax [1, 2-d] imidazole-6,11-dione derivatives bound to the potassium form of human telomere G-quadruplex
2012
In: Taiwan Society for Biochemistry and Molecular Biology
Lin SY, Liu CL, Chang YM, and Hou MH*
Probing the N-terminal domain of coronavirus nucleocapsid protein as a potent target for antiviral drug development
2011
In: 22nd FAOBMB conference
Liu, CL, Chen, IJ and Hou, MH *
Identification of the N-terminal domain of human coronaviral nucleocapsid protein as a potential antiviral target
2010
In: The Taiwan society for biochemistry and molecular biology
Chen, YW and Hou, MH *
Probing the interaction of the residue Y148 in influenza A virus nucleoprotein involved in RNA-binding
2010
In: 4th Asian Bioinorganic Chemistry Conference
Hou, MH *, Lu, WJ, Wang, HM, Yuann, JM, and Huang, CY
The Impact of spermine Competition ON The efficacy of the DNA-Binding of Fe (II), of Co (II), and a Cu (II ) Complexes of dimeric chromomycin A (3)
2010
In: 24th International Conference on Organometallic Chemistry
Hou, MH*, Lu, WJ, Huang, CY, Fan, the RJ, and Yuann, JM
Effects of Polyamines on the DNA-reactive Properties of dimeric Mithramycin complexed with Cobalt (II): Implications for Anticancer Therapy
2010
In: The Taiwan society for biochemistry and molecular biology
Lo, YS, Chiu, YL and Hou, MH *
The crucial role of C-terminal tail of human coronavirus 229E nucleocapsid protein in oligomerization
2009
In: 14th Joint International Conference of Biophysics and Annual Conference of the Biophysical Society of ROC
Chiang, CH, Wu, FC and Hou, MH *
Probing the necessary residues of influenza virus (H1N1) nucleocapsid for RNA-binding
2009
In: 14th Joint International Conference of Biophysics and Annual Conference of the Biophysical Society of ROC
Chiu, YL, Lo, YS and Hou, MH*
Characterization of the C-terminal domain of human coronavirus 229E nucleocapsid protein in RNA-binding and oligomerization
2009
In: VIII European Symposium of The Protein Society
Hou MH*, Chiang CH, Wu FC and Lo YS
Probing the necessary residues of influenza virus (H1N1) nucleoprotein for RNA-binding
2008
In: 23th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan
Liang FY, Lin TJ, Hsu YL, Ying TH and Hou MH*
Prokaryotic expression and antigenicity analysis of human coronavirus OC43 nucleocapsid protein.
2008
In: The 22nd Symposium of The Protein Society 2008
Hou, MH* and Huang, CY
Functional domains identification of human coronavirus 229E nucleocapsid protein (Abstract)
2007
In: Experimental Biology Annual Meeting 2007
Hou, MH*, Hsu, YL, Huang, CY and Chiang, WL
Characterization of human coronavirus OC43 nucleocapsid protein (Abstract)
2007
In: The 21st Symposium of The Protein Society 2007
Hou, MH* and Huang, CY,
The Studies of Biochemical Properties and Stability of Recombinant Human Coronavirus OC43 Nucleocapsid Protein (Abstract)
2005
In: 13th Symposium on Recent Advances in Cellular and Molecular Biology
Hou, MH, Robinson H, Gao YG and Wang AH-J.
The interference mechanism of actinomycin D bound to CTG triplet repeat associated with myotonic dystrophy (Abstract)
2004
In: 21th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan
Hou, MH, Hsu, YL, Tang, TK, Yao, CW, and Wang, AH-J.
Biochemical and Stability s of Recombinant Human coronavirus OC43 nucleocapsid Protein (Abstract)
2004
In: 21th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan
Hou, MH, Lin, HY, Lu, WJ, Kan, LS, and Wang, AH-J
DNA-Binding Characterization of The dimeric chromomycin A3 Complex chelated with of Fe (II) Ion: Sequence by the preference, the DNA cleavage and topoisomerase the I Inhibition (Abstract)
2003
In: 4th East Asian Biophysics Symposium
Hou, MH, Robinson H., Gao YG and Wang AH-J.
The Crystal Structure of The of Mg2 + -.. (Chromomycin A3) 2-D (TTGGCCAA) 2 Complex reveals GGCC Binding specificity of The Drug dimer chelated by Metal Ion (Abstract)
2002
In: The 8th Symposium on Recent Advances in Biophysics
Hou, MH, Robinson H., Gao YG and Wang AH-J.
Crystal structure of actinomycin D bound to the CTG triplet transition series linked to neurological diseases (Abstract)
1999
In: The 5th Symposium on Recent Advances in Biophysics
Hou, MH, Kan LS and Lin SB
The kinetic study of the effect of polyamine on the formation of AT base pair-rich DNA duplexes by surface plasmon resonance (Abstract)
1998
In: The 4th Symposium on Recent Advances in Biophysics
Hou, MH, Kan LS and Lin SB
Stability of DNA duplex re-visit: The effect of polyamine (Abstract)
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