藥 物 設 計 及 化 學 生 物 核 心 實 驗 室
Academic Publications (期刊論文) (* Corresponding Author)
2025
2026
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Shun-Ching Wang, Chang-Chih Hsieh, Tzu-Chun Yuan, Shan-Meng Lin, Chia-Wei Chen, Chih-Chun Chang, Shih-Chun Huang, En-Chi Wang, Yu-Jhen Huang, Ming-Hsi Chiang, Yih-Chern Horng*, and Ming-Hon Hou* (April 2026) Structural basis for asymmetric bis-intercalator targeting of DNA triplex junctions enabling dual inhibition of topoisomerase I and oncogene transcription, Nucleic Acids Research, Accepted.
2025
2021
2021
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Roshan Satange and Ming-Hon Hou* (March 2025)The role of water in mediating DNA structures with epigenetic modifications, higher-order conformations and drug-DNA interactions, RSC Chemical Biology, DOI: 10.1039/D4CB00308J.(IF=4.2, Rank=28%=88/313, Biochemistry & Molecular biology)
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Chih-Chun Chang, Hsin-Ju Li, Roshan Satange, Shan-Meng Lin, Tai-Lin Chen, Chi-Chien Lin, Stephen Neidle, and Ming-Hon Hou* (March 2025)Structural and Functional Insights into Targeting GCCG Sites in the EGFR Promoter by Two DNA Intercalators to Inhibit Breast Cancer Metastasis, Journal of Medicinal Chemistry, Volume 68 Issue 6, 6601–6615(IF=6.9, Rank=4%=3/72,Chemistry & Medicinal)(Featured on Cover)
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Patrick C. Y. Woo,* Yu-Hsi Lin, Ming-Hon Hou, Shao-Yu Huang, Mei-Hui Chen, and Chieh-Chen Huang* (January 2025)Mx. BIOME: A bioinformatics and big data analysis platform in a data explosion era, Microbes & Immunity, Volume X Issue X (February 2025)
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Chun-Wei Lin, Kuo-Yang Huang, Ching-Hsiung Lin, Ming-Hon Hou,* and Sheng-Hao Lin* (January 2025)Diverse clinical outcomes for the EGFR‑mutated and ALK‑rearranged advanced non‑squamous non‑small cell lung cancer, Oncology Letters, Volume 29 Issue 3(IF=2.5, Rank=56.83% = 183/322,Oncology)
2024
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Sankar Panthi, Jhen-Yi Hong, Roshan Satange, Ching-Ching Yu, Long-Yuan Li,* and Ming-Hon Hou* (October 2024) Antiviral drug development by targeting RNA binding site, oligomerization and nuclear export of influenza nucleoprotein, International Journal of Biological Macromolecules, Volume 282, Part 4, 136996 (Review) (IF=7.7, Rank=10.86% = 34/313, Biochemistry & Molecular Biology)
2013
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Mikael Cristofer Sitinjak, Jui-Kai Chen, Fang-Lin Liu , Ming-Hon Hou, Shan-Meng Lin, Hung-Jen Liu, Chi-Young Wang (Aug 2024) Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV), Virus Research, Volume349, 199458, (https://doi.org/10.1016/j.virusres. 2024.199458) (IF=2.5, Rank=43.9%=18/41,Virology)
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Shih-Chun Huang, Chia-Wei Chen, Roshan Satange, Chang-Chih Hsieh, Chih-Chun Chang, Shun-Ching Wang, Chi-Li Peng, Tai-Lin Chen, Ming-Hsi Chiang, Yih-Chern Horng* and Ming-Hon Hou* (July 2024) Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects, Nucleic Acids Research, Volume 52, Issue 15, Pages 9303–9316., https://doi.org/10.1093/nar/gkae643 (IF=16.6, Rank=1.8% = 6/313, Biochemistry & Molecular Biology)
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Shan-Meng Lin, Hsiang-Ti Huang, Pei-Ju Fang, Chi-Fon Chang, Roshan Satange, Chung-ke Chang, Shan-Ho Chou, Stephen Neidle* and Ming-Hon Hou* (June 2024) Structural basis of water-mediated cis Watson-Crick/Hoogsteen base-pair formation in non-CpG methylation, Nucleic Acids Research, Volume 52, Issue 14 Pages 8566–8579., https://doi.org/10.1093/nar/gkae594 (IF=16.6, Rank=1.8% = 6/313, Biochemistry & Molecular Biology)
2018
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Wesley Tien Chiang, Yao-Kai Chang, Wei-Han Hui, Shu-Wei Chang, Chen-Yi Liao, Yi-Chuan Chang, Chun-Jung Chen, Wei-Chen Wang, Chien-Chen Lai, Chun-Hsiung Wang, Siou-Ying Luo, Ya-Ping Huang, Shan-Ho Chou, Tzyy-Leng Horng, Ming-Hon Hou, Stephen P. Muench, Ren-Shiang Chen, Ming-Daw Tsai* and Nien-Jen Hu*(May 2024) Structural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB, Nature Communications, 15, Article number: 3850 (2024) (IF=16.6, Rank=8.2% = 6/73,MULTIDISCIPLINARY SCIENCES )
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Jhen-Yi Hong, Shih-Chao Lin, Kylene Kehn-Hall, Kai-Min Zhang, Shun-Yuan Luo, Hung-Yi Wu, Sui-Yuan Chang, and Ming-Hon Hou* (January 2024) Targeting protein–protein interaction interfaces with anti-viral N protein inhibitor in SARS-CoV-2, Biophysical Journal, Volume 123, Issue 4, 20 February 2024, Pages 478-488 (IF=3.4, Rank=33.6% = 24/70, Biophysics)
2023
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Shun-Ching Wang, Yi-Tsao Chen, Roshan Satange, Jhih-Wei Chu* and Ming-Hon Hou* (May 2023) Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1. Journal of Biological Chemistry, Volume 299, Issue 7, July 2023, 104864 (IF=5.48, Rank=31.64% = 94/297, Biochemistry and Molecular Biology)
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Kuo-Yang Huang, Ying-Lin Hsu, Huang-Chi Chen, Ming-Hwarng Horng, Cheliang Chung, Ching-Hsiung Lin, Jia-Lang Xu* and Ming-Hon Hou* (May 2023) Developing a machine-learning model for real-time prediction of successful extubation in mechanically ventilated patients using time-series ventilator-derived parameters. Frontiers in Medicine, Volume 10 - 2023 | doi: 10.3389/fmed.2023.1167445 (IF=5.05, Rank=30.52% = 53/172, Medicine, General and Internal)
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Roshan Satange, Peng Jin, Ming-Hon Hou, Ambadas B. Rode* (April 2023) Editorial: Non-canonical nucleic acid structures, functions and their applications for understanding human genetic diseases. Frontiers in Genetics, 14:1188978. doi: 10.3389/fgene.2023.1188978 (IF=4.77, Rank=24.30% = 43/175, Medicine, Genetics and Heredity)
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Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle*, and Ming-Hon Hou* (March 2023) Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects. Nucleic Acids Research, volume 51, Issue 8, pages 3540–3555 (IF=19.16, Rank=2.70%= 8/296, Biochemistry & Molecular Biology)
2022
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Roshan Satange, Ambadas B. Rode, and Ming-Hon Hou* (Nov 2022) Revisiting recent unusual drug-DNA complex structures: implications for cancer and neurological disease diagnostics and therapeutics. Bioorganic & Medicinal Chemistry, volume 76, 2022, 117094 (IF=3.46, Rank= 189/296, Biochemistry & Molecular Biology) (Review)
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Roshan Satange, Shih-Hao Kao, Ching-Ming Chien, Shan-Ho Chou, Chi-Chien Lin, Stephen Neidle*, and Ming-Hon Hou* (July 2022) Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Research, volume 50, issue 15, p.8867-8881 (IF=19.16, Rank=2.70%= 8/296, Biochemistry & Molecular Biology)
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Jia-Ning Hsu, Jyun-Siao Chen, Shan-Meng Lin, Yi-Jheng Chen, Jhen-Yi Hong, U-Ser Jeng, Shun-Yuan Luo*, and Ming-Hon Hou* (April 2022) Targeting the N-terminus domain of the coronavirus nucleocapsid protein induces abnormal oligomerization via allosteric modulation. Frontiers in Molecular Biosciences, Volume 9, Article 871499, 2022. (IF=6.11, Rank=24.74%= 73/295, Biochemistry and Molecular Biology)
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Chun-Wei Lin, Kuo-Yang Huang, Ching-Hsiung Lin, Bing-Yen Wang, Chew-Teng Kor, Ming-Hon Hou, and Sheng-Hao Lin* (Feb 2022) Video-Assisted Thoracoscopic Surgery in Community-Acquired Thoracic Empyema: Analysis of Risk Factors for Mortality. Surgical Infections Vol. 23, No. 2. 191-198 (IF=1.85)
2021
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Tai-Lin Chen, Anilkumar S. Patel, Vicky Jain, Ramajayam Kuppusamy, Yi-Wen Lin, Ming-Hon Hou, Tsann-Long Su*, and Te-Chang Lee* (August 2021) Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links. Journal of Medicinal Chemistry, volume 64, 17, pages 12469–12486. (IF=8.03, Rank=4.0%= 3/63, Medicinal Chemistry)
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Chung-ke Chang, Shan-Meng Lin, Roshan Satange, Shih-Chao Lin, Sin-Cih Sun, Hung-Yi Wu, Kylene Kehn-Hall and Ming-Hon Hou* (April 2021) Targeting protein-protein interaction interfaces in COVID-19 drug discovery Computational and Structural Biotechnology Journal, volume 19, 2246-2255. (IF=6.15, Rank=23.64%= 70/296, Biochemistry & Molecular Biology) (Review)
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Cyong-Ru Jhan, Roshan Satange, Shun-Ching Wang, Jing-Yi Zeng, Yih-Chern Horng, Peng Jin, Stephen Neidle, and Ming-Hon Hou* (April 2021) Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Research, Volume 49, issue 16, p.9526-9538. (IF=19.16 , Rank=2.70%= 8/296, Biochemistry & Molecular Biology) (Featured on Cover)
2020
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Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chun Chang, ZI-Lun Lai, Lauren D. Hagler, Steven C. Zimmerman*, and Ming-Hon Hou* (June 2020) Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA. Journal of the American Chemical Society, 142, 25, 11165–11172. (IF=14.695), Rank=6.9%= 12/172, Chemistry and Multidisciplinary)
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Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-ke Chang, Ching-Ming Chien, Yong-Sheng Wang, Hung-Yi Wu, U-Ser Jeng, Kylene Kehn-Hall and Ming-Hon Hou* (Feb 2020) Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design. Journal of Medicinal Chemistry, 63, 6, 3131–3141 (IF=6.054, Rank=4.9%= 3/61, Medicinal Chemistry) (Featured on Cover)
2019
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Jyung-Hurng Liu*, Jun-Yi Yang, Duen-Wei Hsu, Yi-Hua Lai, Yun-Pei Li, Yi-Rung Tsai, and Ming-Hon Hou (Oct 2019) Crystal Structure-Based Exploration of Arginine-Containing Peptide Binding in the ADP-Ribosyltransferase Domain of the Type III Effector XopAI Protein. International Journal of Molecular Sciences, 20(20), 5085 (IF=4.183, Rank=26%= 78/299, Biochemistry & Molecular Biology)
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Roshan Satange, Chien-Ying Chuang, Stephen Neidle and Ming-Hon Hou* (Jul 2019) Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Research, 47(16):8899–8912. (IF=11.147 , Rank=4.68%= 14/299, Biochemistry & Molecular Biology)
2018
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Chen YW; Satange R; Wu PC; Jhan CR; Chang CK; Chung KR; Waring MJ; Lin SW; Hsieh LC; Hou MH* (Sep 2018) CoII(Chromomycin)2 complex induces a conformational change of CCG repeats from i-Motif to base-extruded DNA duplex. International Journal of Molecular Sciences, 19(9), 2796. (IF=4.183, Rank=26%= 78/299, Biochemistry & Molecular Biology)
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Roshan Satange, Chung-ke Chang and Ming-Hon Hou* (Jun/Jul 2018) A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding. Nucleic Acids Research, 46(13):6416-6434. (IF=11.147, Rank=4.68%= 14/299, Biochemistry & Molecular Biology) (Review)
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Liu CH, Chen YT, Hou MH, Hu NJ, Chen CS, Shaw JF (May/Jun 2018) Crystallographic analysis of the Staphylococcus epidermidis lipase involved in esterification in aqueous solution. Acta Crystallographica Section F-Structural Biology Communications, 74(Pt 6):351-354. (IF=1.199, Rank=65.3%= 17/26, Crystallography)
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Pei-Ching Wu, Shu-Ling Tzeng, Chung-ke Chang, Ya-Fen Kao, Michael J. Waring and Ming-Hon Hou* (May/Aug 2018) Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex. Nucleic Acids Research, 46(14):7396–7404 (IF=11.147, Rank=4.68%= 14/299, Biochemistry & Molecular Biology) (Featured on cover)
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Ming-Hon Hou*, Roshan Satange and Chung-ke Chang, Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases, Chemical Biology No. 7, DNA-targeting Molecules as Therapeutic Agents, The Royal Society of Chemistry, Mar 2018, Chapter 6, 144-174 (DOI- 10.1039/9781788012928-00144).
2017
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Huang TY; Chang CK; Kao YF; Chin CH; Ni CW; Hsu HY; Hu NJ; Hsieh LC; Chou SH; Lee IR*; Hou MH* (Aug/Sep 2017) Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion. Proceedings of the National Academy of Sciences of the United States of America, 114(36):9535-9540. (IF=9.58, Rank=10.1%= 7/69, Multidisciplinary Sciences)
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Tseng WH; Chang CK; Wu PC; Hu NJ; Lee GH; Tzeng CC; Neidle S; Hou MH* (May/Jul 2017) Induced‐Fit Recognition of CCG Trinucleotide Repeats by a Nickel–Chromomycin Complex Resulting in Large‐Scale DNA Deformation. Angewandte Chemie-International Edition, 56(30):8761-8765 (IF=12.257, Rank=9.88%= 17/172, Chemistry, Multidisciplinary)
2016
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Lin YH; Chuang SM; Wu PC; Chen CL; Jeyachandran S; Lo SC; Huang HS; Hou MH* (Aug 2016) Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. Scientific Reports, 6:31019. (IF=4.011, Rank=21.7%= 15/69, Multidisciplinary Sciences)
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Liu CL; Hung HC; Lo SC; Chiang CH; Chen IJ; Hsu JT; Hou MH* (Feb 2016) Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development. Scientific Reports, 6:21662. (IF=4.011, Rank=21.7%= 15/69, Multidisciplinary Sciences)
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Chang CK; Lo SC; Wang YS; Hou MH* (Dec 2015/Apr 2016) Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein. Drug Discovery Today, 21(4):562-72. (IF=6.88 , Rank=4.49%= 12/267, Pharmacology & Pharmacy) (Review)
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Hou MH*; Chuang CY; Ko TP; Hu NJ; Chou CC; Shih YP; Ho CL; Wang AH (Nov 2015/Jan 2016) Crystal structure of vespid phospholipase A(1) reveals insights into the mechanism for cause of membrane dysfunction. Insect Biochemistry and Molecular Biology, 68:79-88 (IF=3.618, Rank=5.1%= 5/98, Entomology)
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Chang CK; Jeyachandran S; Hu NJ; Liu CL; Lin SY; Wang YS; Chang YM; Hou MH* (Nov 2015/Jan 2016) Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein. Molecular BioSystems, 12(1):59-66 (IF=2.855, Rank=50.8%= 152/299, Biochemistry & Molecular Biology)
2015
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Wang YS; Chang CK; Hou MH* (Jul/Aug 2015) Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein. Acta crystallographica Section F-Structural Biology Communications, 71(Pt 8):977-80. (IF=1.199, Rank=65.3% =17/26, Crystallography)
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Chang CK; Jhan CR; Hou MH* (Jul 2015) The Interaction of DNA-Binding Ligands with Trinucleotide-Repeat DNA: Implications for Therapy and Diagnosis of Neurological Disorders. Current Topics in Medicinal Chemistry, 15(14):1398-408 (IF=3.442, Rank=32.7%= 20/61, Chemistry, Medicinal) (Review)
2014
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Chen YW; Jhan CR; Neidle S; Hou MH* (Aug/Sep 2014) Structural Basis for the Identification of an i-Motif Tetraplex Core with a Parallel-Duplex Junction as a Structural Motif in CCG Triplet Repeats. Angewandte Chemie-International Edition, 53(40):10682-6 (IF=12.257, Rank=9.88% = 17/172, Chemistry, Multidisciplinary)
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Lin SY; Liu CL; Chang YM; Zhao J; Perlman S; Hou MH* (Feb/Mar 2014) Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target. Journal of Medicinal Chemistry, 57(6):2247-57 (IF=6.054, Rank=4.91%= 3/61, Chemistry, Medicinal)
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Chang CK; Hou MH; Chang CF; Hsiao CD; Huang TH* (Jan/Mar 2014) The SARS coronavirus nucleocapsid protein - forms and functions. Antiviral Research, 103, 39-50 (IF=4.13, Rank=18.7%= 50/267, Pharmacology & Pharmacy) (Review)
2013
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Chen IJ; Yuann JM; Chang YM; Lin SY; Zhao J; Perlman S; Shen YY; Huang TH; Hou MH* (Mar/Jun 2013) Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein. Biochimica et biophysica acta-Proteins and Proteomics, 1834(6):1054-62. (IF=2.54 , Rank=46.5%= 34/73, Biophysics)
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Lo YS; Tseng WH; Chuang CY; Hou MH* (Feb/Apr 2013) The structural basis of actinomycin D–binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats. Nucleic Acids Research, 41(7):4284-94. (IF=11.147 , Rank=4.68%= 14/299, Biochemistry & Molecular Biology)
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Lo YS; Lin SY; Wang SM; Wang CT; Chiu YL; Huang TH; Hou MH* (Nov 2012/Jan 2013) Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein. FEBS Letters, 587(2):120-7. (IF=2.675 , Rank=41%= 30/73, Biophysics)
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Liang FY; Lin LC; Ying TH; Yao CW; Tang TK; Chen YW; Hou MH* (Nov 2012/Feb 2013) Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: implications for the diagnosis of coronavirus infection. Journal of Virological Methods, 187(2):413-20. (IF=1.746 , Rank=70.9%= 115/162, Biotechnology & Applied Microbiology)
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Kuo SM; Kao HW; Hou MH; Wang CH; Lin SH; Su HL (Oct 2012/Mar 2013) Evolution of infectious bronchitis virus in Taiwan: positively selected sites in the nucleocapsid protein and their effects on RNA-binding activity. Veterinary Microbiology, 162(2-4):408-18. (IF=2.791, Rank=4.96%= 7/141, Veterinary Sciences)
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Hsu CW; Kuo CF; Chuang SM; Hou MH* (Oct 2012/Feb 2013) Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex. BioMetals, 26(1):1-12. (IF=2.455, Rank=61.2%= 183/299, Biochemistry & Molecular Biology)
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Chen YW; Hou MH* (Dec 2012/Apr 2013) The binding of the Co (II) complex of dimeric chromomycin A3 to GC sites with flanking G: G mismatches. Journal of Inorganic Biochemistry, 121:28-36. (IF=3.224, Rank=24.4%= 11/45, Chemistry, Inorganic & Nuclear)
2012
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Yuann JM; Tseng WH; Lin HY; Hou MH* (Jun/Sep 2012) The effects of loop size on Sac7d-hairpin DNA interactions. Biochimica et Biophysica Acta-Proteins and Proteomics, 1824(9):1009-15 (IF=2.54, Rank=46.5%= 34/73, Biophysics)
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Wu MR; Hou MH; Lin YL; Kuo CF* (Jul 2012) 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. Journal of Agricultural and Food Chemistry, 60(29):7262-9 (IF=3.571, Rank=5.26%= 3/57, Agriculture, Multidisciplinary)
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Wang SY; Lee AY; Lai YH; Chen JJ; Wu WL; Yuann JM; Su WL; Chuang SM; Hou MH* (Nov 2012) Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication. PLOS One, 7(11):e47101 (IF=2.776, Rank=34.7%= 24/69, Multidisciplinary Sciences)
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Hung HC; Liu CL; Hsu JT; Horng JT; Fang MY; Wu SY; Ueng SH; Wang MY; Yaw CW; Hou MH* (Jul/Aug 2012) Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching. Analytical Chemistry, 84(15):6391-9 (IF=6.35, Rank=8.33%= 7/84, Chemistry, Analytical)
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Hsu CW; Chuang SM; Wu WL; Hou MH* (Sep 2012) The crucial role of divalent metal ions in the DNA-acting efficacy and inhibition of the transcription of dimeric chromomycin A3. PLOS One, 7(9):e43792 (IF=2.776, Rank=34.7%= 24/69, Multidisciplinary Sciences)
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Chang YM; Chen CK; Hou MH* (Mar 2012) Conformational changes in DNA upon ligand binding monitored by circular dichroism. International Journal of Molecular Sciences,13(3):3394-413 (IF=4.183, Rank=26%= 78/299, Biochemistry & Molecular Biology) (Review)
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Chang YM; Chen CK; Chang YC; Jeng WY; Hou MH; Wang AH* (Sep 2012) Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis. PLOS One, 7(9):e45665 (IF=2.776, Rank=34.7%= 24/69, Multidisciplinary Sciences)
2011-2001
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Kuo SM; Wang CH; Hou MH; Huang YP; Kao HW*; Su HL* (Feb/Aug 2010) Evolution of infectious bronchitis virus in Taiwan: characterisation of RNA recombination in the nucleocapsid gene. Veterinary Microbiology, 144(3-4):293-302.
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Chen IJ; Chou CC; Liu CL; Lee CC; Kan LS; Hou MH* (Jun/Jul 2010) Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid protein. Acta Crystallographica Section F-Structural Biology And Crystallization Communications, 66(Pt 7):815-8.
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Lu WJ; Wang HM; Yuann JM; Huang CY; Hou MH* (Sep/Dec 2009) The impact of spermine competition on the efficacy of DNA-binding Fe (II), Co (II) Complexes of dimeric chromomycin A (3). Journal Of Inorganic Biochemistry, 103(12):1626-33.
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Huang CY; Hsu YL; Chiang WL; Hou MH* (Aug/Nov 2009) Elucidation of the stability and functional regions of the human coronavirus OC43 nucleocapsid protein. Protein Science, 18(11):2209-18.
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Hou MH*, Lu WJ, Huang CY, Fan RJ, Yuann JM (Apr/Jun 2009) Effects of Polyamines on the DNA-Reactive Properties of Dimeric Mithramycin Complexed with Cobalt(II): Implications for Anticancer Therapy. Biochemistry, 48 (22), pp 4691–4698.
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Kuo,CF*; Hou,MH; Wang,TS; Chyau,CC; Chen,YT (Mar/Oct 2009) Enhanced antioxidant activity of Monascus pilosus fermented products by addition of ginger to the medium. FOOD CHEMISTRY. 116,(4);915-922.
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Chou,CC; Hou,MH* (Nov/Dec 2008) Crystallization and preliminary X-ray diffraction analysis of phospholipase A(1) isolated from hornet (Vespa basalis) venom. Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 64(Pt 12):1118-20.
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Hou MH*; Lu WJ; Lin HY; Yuann JM (Apr/May 2008) Studies of sequence-specific DNA binding, DNA cleavage, and topoisomerase inhibition by the dimeric chromomycin A(3) complexed with Fe-II. Biochemistry, 47(20):5493-502.
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Tang TK; Wu MP; Chen ST; Hou MH; Hong MH; Pan FM; Yu HM; Chen JH; Yao CW; Wang AH* (Mar 2005) Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses. Proteomics, 5(4):925-37.
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Hou MH; Wang AH* (Mar 2005) Mithramycin forms a stable dimeric complex by chelating with Fe (II): DNA-interacting characteristics, cellular permeation and cytotoxicity. Nucleic Acids Research, 33(4):1352-61.
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Hou MH; Robinson H; Gao YG; Wang AH (Apr 2004) Crystal structure of the [Mg2+-(chromomycin A(3))(2)]-d(TTGGCCAA)(2) complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion. Nucleic Acids Research, 32(7):2214-22. (Featured on Cover)
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Hou, MH; Robinson H; Gao YG; Wang AH* (Nov 2002) Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases. Nucleic Acids Research, 30(22):4910-7. (On cover)
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Hou MH; Lin SB; Yuann JM; Lin WC; Wang AH*; Kan Ls L (Dec 2001) Effects of Polyamines ON the Thermal Stability and formation Kinetics of the DNA duplexes with Abnormal Structure. Nucleic Acids Research, 29(24):5121-8.
會議演講 (Invited speeches)
Month, Year | Title | Conference/Place |
|---|---|---|
March, 2025 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Joint Annual Conference of Biomedical Science |
December, 2025 | Structure-Guided Development of Small Molecules Targeting Functional DNAs for Cancer Therapy | In: IAMS Seminar in Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan |
November, 2023 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Department of Biological Sciences, National Sun Yat-sen University, Taiwan.(30 November 2023) |
December, 2023 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Shih Chien University, Taiwan. (25 December 2023. ) |
March, 2024 | Structural Basis of Water-Mediated Hoogsteen Base-Pair Formation in Non-CpG Methylation | In: 2024 Chemistry National Meeting, Tamkang University, Taiwan.(31 March 2024) |
April, 2024 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Department of Chemistry and Biochemistry, National Chung Cheng University(23 April 2024) |
May, 2024 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: College of Medicine, National Taiwan University, Taiwan. (1 May 2024) |
November 2023 | Targeting protein-protein interaction interfaces with Anti-viral N protein inhibitor in SARS-CoV-2 | In: The 17th International Symposium on Biocatalysis and Agricultural Biotechnology; November 8-10, 2023, National Chung Hsing University, Taichung, Taiwan. |
September 2023 | Research Life Experience Sharing | In: National Sun Yat-Sen University, Kaohsiung, Taiwan (September 15, 2023) |
August 2023 | Synergistic binding of two distinct antibiotic intercalators to mismatch sites and their applications in cancer therapy | In: National Tsing Hua University; Hsinchu, Taiwan (August 31, 2023) |
July 2023 | Targeting trinucleotide repeats using DNA binding small molecules with conformational polymorphism | In: Department of Chemistry, National Taiwan University, Taiwan (July 12, 2023) |
May, 2023 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Lectures of NTHU Chemistry, National Tsing Hua University, Taiwan (May 10, 2023) |
研討會論文 (Conference and Seminar poster presentations)
Year | Conference/Seminar name | Authors | Title |
|---|---|---|---|
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Jia-Rong Tsai, Ming-Hon Hou* | Structural basic and conformational transitions of Actinomycin D-Induced Higher-Order DNA Structures in Mismatched Sequences |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Yen-Yi Lee, Mig-Hon Hou* | Probing the binding mechanism of Actinomycin D and Echinomycin to bulged DNA |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Roshani Bele, Pi-Chung Wang*, Ming-Hon Hou* | Performance improvement of packet classification algorithm by using Decision trees: Implication for biomedical data management |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Jia-Ying Chen, Ming-Hon Hou* | Exploring the therapeutic potential of NA compounds and their application in anti-colorectal cancer strategies |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Shih-Chun Huang, Ming-Hon Hou* | Symmetric and asymmetric bisacridine derivatives inhibit cancer cell proliferation via binding DNA duplexes |
2023 | In: Chemistry National Meeting, National University of Kaohsiung, Taiwan | Shih-Chun Huang, Ming-Hon Hou* | Structure based study of the binding mechanism of bis-intercalator to DNA duplex |
2023 | In: Chemistry National Meeting, National University of Kaohsiung, Taiwan | Chia-Yu Chen, Ming-Hon Hou* | Structure-based studies of actinomycin D and Z3 molecules targeting Z-DNA
sequence for novel anti-cancer approach |
2023 | In: Chemistry National Meeting, National University of Kaohsiung, Taiwan | Jia-Rong Tsai, Ming-Hon Hou* | Structural-based study of a Four-Way Junction like DNA structure formation
containing a T:T mismatch induced by actinomycin D |
2022 | In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan | Tsai-Hsuan Han, Chih-Chun Chang and Ming-Hon Hou* | The mechanism study of the clinical DNA intercalator- Doxorubicin targeting DNA duplexes for developing potential cancer therapy |
2022 | In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan | Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle and Ming-Hon Hou* | Targeting DNA mismatches by two distinct intercalators exhibit synergistic effect against mismatch repair deficient cancers |
2022 | In: Functional Nucleic Acids INDIA-EMBO Lecture Course 2022, Faridabad, Delhi NCR, India | Shun-Ching Wang and Ming-Hon Hou* | Structural basis of Myotonic Dystrophy type 1 CUG repeat RNA crystal reveal multiple water mediated U-U mismatches (online) |
2022 | In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan | Jhen-Yi Hong and Ming-Hon Hou* | Targeting the N-terminus domain of the coronavirus nucleocapsid protein induces abnormal oligomerization via allosteric modulation |