藥 物 設 計 及 化 學 生 物 核 心 實 驗 室
2021
2013
Academic Publications (期刊論文) (* Corresponding Author)
2024
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Jhen-Yi Hong, Shih-Chao Lin, Kylene Kehn-Hall, Kai-Min Zhang, Shun-Yuan Luo, Hung-Yi Wu, Sui-Yuan Chang, and Ming-Hon Hou* (January 2024) Targeting protein–protein interaction interfaces with anti-viral N protein inhibitor in SARS-CoV-2, Biophysical Journal, Accepted (IF=3.4, Rank=33.6% = 24/70, Biophysics)
2023
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Shun-Ching Wang, Yi-Tsao Chen, Roshan Satange, Jhih-Wei Chu* and Ming-Hon Hou* (May 2023) Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1. Journal of Biological Chemistry, Accepted (IF=5.48, Rank=31.64% = 94/297, Biochemistry and Molecular Biology)
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Kuo-Yang Huang, Ying-Lin Hsu, Huang-Chi Chen, Ming-Hwarng Horng, Cheliang Chung, Ching-Hsiung Lin, Jia-Lang Xu* and Ming-Hon Hou* (May 2023) Developing a machine-learning model for real-time prediction of successful extubation in mechanically ventilated patients using time-series ventilator-derived parameters. Frontiers in Medicine, Volume 10 - 2023 | doi: 10.3389/fmed.2023.1167445 (IF=5.05, Rank=30.52% = 53/172, Medicine, General and Internal)
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Roshan Satange, Peng Jin, Ming-Hon Hou, Ambadas B. Rode* (April 2023) Editorial: Non-canonical nucleic acid structures, functions and their applications for understanding human genetic diseases. Frontiers in Genetics, 14:1188978. doi: 10.3389/fgene.2023.1188978 (IF=4.77, Rank=24.30% = 43/175, Medicine, Genetics and Heredity)
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Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle*, and Ming-Hon Hou* (March 2023) Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects. Nucleic Acids Research, volume 51, Issue 8, pages 3540–3555 (IF=19.16, Rank=2.70%= 8/296, Biochemistry & Molecular Biology)
2022
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Roshan Satange, Ambadas B. Rode, and Ming-Hon Hou* (Nov 2022) Revisiting recent unusual drug-DNA complex structures: implications for cancer and neurological disease diagnostics and therapeutics. Bioorganic & Medicinal Chemistry, volume 76, 2022, 117094 (IF=3.46, Rank= 189/296, Biochemistry & Molecular Biology) (Review)
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Roshan Satange, Shih-Hao Kao, Ching-Ming Chien, Shan-Ho Chou, Chi-Chien Lin, Stephen Neidle*, and Ming-Hon Hou* (July 2022) Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Research, volume 50, issue 15, p.8867-8881 (IF=19.16, Rank=2.70%= 8/296, Biochemistry & Molecular Biology)
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Jia-Ning Hsu, Jyun-Siao Chen, Shan-Meng Lin, Yi-Jheng Chen, Jhen-Yi Hong, U-Ser Jeng, Shun-Yuan Luo*, and Ming-Hon Hou* (April 2022) Targeting the N-terminus domain of the coronavirus nucleocapsid protein induces abnormal oligomerization via allosteric modulation. Frontiers in Molecular Biosciences, Volume 9, Article 871499, 2022. (IF=6.11, Rank=24.74%= 73/295, Biochemistry and Molecular Biology)
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Chun-Wei Lin, Kuo-Yang Huang, Ching-Hsiung Lin, Bing-Yen Wang, Chew-Teng Kor, Ming-Hon Hou, and Sheng-Hao Lin* (Feb 2022) Video-Assisted Thoracoscopic Surgery in Community-Acquired Thoracic Empyema: Analysis of Risk Factors for Mortality. Surgical Infections Vol. 23, No. 2. 191-198 (IF=1.85)
2021
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Tai-Lin Chen, Anilkumar S. Patel, Vicky Jain, Ramajayam Kuppusamy, Yi-Wen Lin, Ming-Hon Hou, Tsann-Long Su*, and Te-Chang Lee* (August 2021) Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[g]pyrrolo[2,1-a]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links. Journal of Medicinal Chemistry, volume 64, 17, pages 12469–12486. (IF=8.03, Rank=4.0%= 3/63, Medicinal Chemistry)
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Chung-ke Chang, Shan-Meng Lin, Roshan Satange, Shih-Chao Lin, Sin-Cih Sun, Hung-Yi Wu, Kylene Kehn-Hall and Ming-Hon Hou* (April 2021) Targeting protein-protein interaction interfaces in COVID-19 drug discovery Computational and Structural Biotechnology Journal, volume 19, 2246-2255. (IF=6.15, Rank=23.64%= 70/296, Biochemistry & Molecular Biology) (Review)
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Cyong-Ru Jhan, Roshan Satange, Shun-Ching Wang, Jing-Yi Zeng, Yih-Chern Horng, Peng Jin, Stephen Neidle, and Ming-Hon Hou* (April 2021) Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Research, Volume 49, issue 16, p.9526-9538. (IF=19.16 , Rank=2.70%= 8/296, Biochemistry & Molecular Biology) (Featured on Cover)
2020
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Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chun Chang, ZI-Lun Lai, Lauren D. Hagler, Steven C. Zimmerman*, and Ming-Hon Hou* (June 2020) Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA. Journal of the American Chemical Society, 142, 25, 11165–11172. (IF=14.695), Rank=6.9%= 12/172, Chemistry and Multidisciplinary)
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Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-ke Chang, Ching-Ming Chien, Yong-Sheng Wang, Hung-Yi Wu, U-Ser Jeng, Kylene Kehn-Hall and Ming-Hon Hou* (Feb 2020) Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design. Journal of Medicinal Chemistry, 63, 6, 3131–3141 (IF=6.054, Rank=4.9%= 3/61, Medicinal Chemistry) (Featured on Cover)
2019
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Jyung-Hurng Liu*, Jun-Yi Yang, Duen-Wei Hsu, Yi-Hua Lai, Yun-Pei Li, Yi-Rung Tsai, and Ming-Hon Hou (Oct 2019) Crystal Structure-Based Exploration of Arginine-Containing Peptide Binding in the ADP-Ribosyltransferase Domain of the Type III Effector XopAI Protein. International Journal of Molecular Sciences, 20(20), 5085 (IF=4.183, Rank=26%= 78/299, Biochemistry & Molecular Biology)
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Roshan Satange, Chien-Ying Chuang, Stephen Neidle and Ming-Hon Hou* (Jul 2019) Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Research, 47(16):8899–8912. (IF=11.147 , Rank=4.68%= 14/299, Biochemistry & Molecular Biology)
2018
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Chen YW; Satange R; Wu PC; Jhan CR; Chang CK; Chung KR; Waring MJ; Lin SW; Hsieh LC; Hou MH* (Sep 2018) CoII(Chromomycin)2 complex induces a conformational change of CCG repeats from i-Motif to base-extruded DNA duplex. International Journal of Molecular Sciences, 19(9), 2796. (IF=4.183, Rank=26%= 78/299, Biochemistry & Molecular Biology)
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Roshan Satange, Chung-ke Chang and Ming-Hon Hou* (Jun/Jul 2018) A survey of recent unusual high-resolution DNA structures provoked by mismatches, repeats and ligand binding. Nucleic Acids Research, 46(13):6416-6434. (IF=11.147, Rank=4.68%= 14/299, Biochemistry & Molecular Biology) (Review)
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Liu CH, Chen YT, Hou MH, Hu NJ, Chen CS, Shaw JF (May/Jun 2018) Crystallographic analysis of the Staphylococcus epidermidis lipase involved in esterification in aqueous solution. Acta Crystallographica Section F-Structural Biology Communications, 74(Pt 6):351-354. (IF=1.199, Rank=65.3%= 17/26, Crystallography)
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Pei-Ching Wu, Shu-Ling Tzeng, Chung-ke Chang, Ya-Fen Kao, Michael J. Waring and Ming-Hon Hou* (May/Aug 2018) Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex. Nucleic Acids Research, 46(14):7396–7404 (IF=11.147, Rank=4.68%= 14/299, Biochemistry & Molecular Biology) (Featured on cover)
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Ming-Hon Hou*, Roshan Satange and Chung-ke Chang, Binding of Small Molecules to Trinucleotide DNA Repeats Associated with Neurodegenerative Diseases, Chemical Biology No. 7, DNA-targeting Molecules as Therapeutic Agents, The Royal Society of Chemistry, Mar 2018, Chapter 6, 144-174 (DOI- 10.1039/9781788012928-00144).
2017
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Huang TY; Chang CK; Kao YF; Chin CH; Ni CW; Hsu HY; Hu NJ; Hsieh LC; Chou SH; Lee IR*; Hou MH* (Aug/Sep 2017) Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion. Proceedings of the National Academy of Sciences of the United States of America, 114(36):9535-9540. (IF=9.58, Rank=10.1%= 7/69, Multidisciplinary Sciences)
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Tseng WH; Chang CK; Wu PC; Hu NJ; Lee GH; Tzeng CC; Neidle S; Hou MH* (May/Jul 2017) Induced‐Fit Recognition of CCG Trinucleotide Repeats by a Nickel–Chromomycin Complex Resulting in Large‐Scale DNA Deformation. Angewandte Chemie-International Edition, 56(30):8761-8765 (IF=12.257, Rank=9.88%= 17/172, Chemistry, Multidisciplinary)
2016
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Lin YH; Chuang SM; Wu PC; Chen CL; Jeyachandran S; Lo SC; Huang HS; Hou MH* (Aug 2016) Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA. Scientific Reports, 6:31019. (IF=4.011, Rank=21.7%= 15/69, Multidisciplinary Sciences)
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Liu CL; Hung HC; Lo SC; Chiang CH; Chen IJ; Hsu JT; Hou MH* (Feb 2016) Using mutagenesis to explore conserved residues in the RNA-binding groove of influenza A virus nucleoprotein for antiviral drug development. Scientific Reports, 6:21662. (IF=4.011, Rank=21.7%= 15/69, Multidisciplinary Sciences)
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Chang CK; Lo SC; Wang YS; Hou MH* (Dec 2015/Apr 2016) Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein. Drug Discovery Today, 21(4):562-72. (IF=6.88 , Rank=4.49%= 12/267, Pharmacology & Pharmacy) (Review)
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Hou MH*; Chuang CY; Ko TP; Hu NJ; Chou CC; Shih YP; Ho CL; Wang AH (Nov 2015/Jan 2016) Crystal structure of vespid phospholipase A(1) reveals insights into the mechanism for cause of membrane dysfunction. Insect Biochemistry and Molecular Biology, 68:79-88 (IF=3.618, Rank=5.1%= 5/98, Entomology)
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Chang CK; Jeyachandran S; Hu NJ; Liu CL; Lin SY; Wang YS; Chang YM; Hou MH* (Nov 2015/Jan 2016) Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein. Molecular BioSystems, 12(1):59-66 (IF=2.855, Rank=50.8%= 152/299, Biochemistry & Molecular Biology)
2015
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Wang YS; Chang CK; Hou MH* (Jul/Aug 2015) Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein. Acta crystallographica Section F-Structural Biology Communications, 71(Pt 8):977-80. (IF=1.199, Rank=65.3% =17/26, Crystallography)
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Chang CK; Jhan CR; Hou MH* (Jul 2015) The Interaction of DNA-Binding Ligands with Trinucleotide-Repeat DNA: Implications for Therapy and Diagnosis of Neurological Disorders. Current Topics in Medicinal Chemistry, 15(14):1398-408 (IF=3.442, Rank=32.7%= 20/61, Chemistry, Medicinal) (Review)
2014
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Chen YW; Jhan CR; Neidle S; Hou MH* (Aug/Sep 2014) Structural Basis for the Identification of an i-Motif Tetraplex Core with a Parallel-Duplex Junction as a Structural Motif in CCG Triplet Repeats. Angewandte Chemie-International Edition, 53(40):10682-6 (IF=12.257, Rank=9.88% = 17/172, Chemistry, Multidisciplinary)
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Lin SY; Liu CL; Chang YM; Zhao J; Perlman S; Hou MH* (Feb/Mar 2014) Structural basis for the identification of the N-terminal domain of coronavirus nucleocapsid protein as an antiviral target. Journal of Medicinal Chemistry, 57(6):2247-57 (IF=6.054, Rank=4.91%= 3/61, Chemistry, Medicinal)
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Chang CK; Hou MH; Chang CF; Hsiao CD; Huang TH* (Jan/Mar 2014) The SARS coronavirus nucleocapsid protein - forms and functions. Antiviral Research, 103, 39-50 (IF=4.13, Rank=18.7%= 50/267, Pharmacology & Pharmacy) (Review)
2013
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Chen IJ; Yuann JM; Chang YM; Lin SY; Zhao J; Perlman S; Shen YY; Huang TH; Hou MH* (Mar/Jun 2013) Crystal structure-based exploration of the important role of Arg106 in the RNA-binding domain of human coronavirus OC43 nucleocapsid protein. Biochimica et biophysica acta-Proteins and Proteomics, 1834(6):1054-62. (IF=2.54 , Rank=46.5%= 34/73, Biophysics)
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Lo YS; Tseng WH; Chuang CY; Hou MH* (Feb/Apr 2013) The structural basis of actinomycin D–binding induces nucleotide flipping out, a sharp bend and a left-handed twist in CGG triplet repeats. Nucleic Acids Research, 41(7):4284-94. (IF=11.147 , Rank=4.68%= 14/299, Biochemistry & Molecular Biology)
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Lo YS; Lin SY; Wang SM; Wang CT; Chiu YL; Huang TH; Hou MH* (Nov 2012/Jan 2013) Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein. FEBS Letters, 587(2):120-7. (IF=2.675 , Rank=41%= 30/73, Biophysics)
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Liang FY; Lin LC; Ying TH; Yao CW; Tang TK; Chen YW; Hou MH* (Nov 2012/Feb 2013) Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: implications for the diagnosis of coronavirus infection. Journal of Virological Methods, 187(2):413-20. (IF=1.746 , Rank=70.9%= 115/162, Biotechnology & Applied Microbiology)
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Kuo SM; Kao HW; Hou MH; Wang CH; Lin SH; Su HL (Oct 2012/Mar 2013) Evolution of infectious bronchitis virus in Taiwan: positively selected sites in the nucleocapsid protein and their effects on RNA-binding activity. Veterinary Microbiology, 162(2-4):408-18. (IF=2.791, Rank=4.96%= 7/141, Veterinary Sciences)
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Hsu CW; Kuo CF; Chuang SM; Hou MH* (Oct 2012/Feb 2013) Elucidation of the DNA-interacting properties and anticancer activity of a Ni(II)-coordinated mithramycin dimer complex. BioMetals, 26(1):1-12. (IF=2.455, Rank=61.2%= 183/299, Biochemistry & Molecular Biology)
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Chen YW; Hou MH* (Dec 2012/Apr 2013) The binding of the Co (II) complex of dimeric chromomycin A3 to GC sites with flanking G: G mismatches. Journal of Inorganic Biochemistry, 121:28-36. (IF=3.224, Rank=24.4%= 11/45, Chemistry, Inorganic & Nuclear)
2012
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Yuann JM; Tseng WH; Lin HY; Hou MH* (Jun/Sep 2012) The effects of loop size on Sac7d-hairpin DNA interactions. Biochimica et Biophysica Acta-Proteins and Proteomics, 1824(9):1009-15 (IF=2.54, Rank=46.5%= 34/73, Biophysics)
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Wu MR; Hou MH; Lin YL; Kuo CF* (Jul 2012) 2,4,5-TMBA, a natural inhibitor of cyclooxygenase-2, suppresses adipogenesis and promotes lipolysis in 3T3-L1 adipocytes. Journal of Agricultural and Food Chemistry, 60(29):7262-9 (IF=3.571, Rank=5.26%= 3/57, Agriculture, Multidisciplinary)
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Wang SY; Lee AY; Lai YH; Chen JJ; Wu WL; Yuann JM; Su WL; Chuang SM; Hou MH* (Nov 2012) Spermine attenuates the action of the DNA intercalator, actinomycin D, on DNA binding and the inhibition of transcription and DNA replication. PLOS One, 7(11):e47101 (IF=2.776, Rank=34.7%= 24/69, Multidisciplinary Sciences)
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Hung HC; Liu CL; Hsu JT; Horng JT; Fang MY; Wu SY; Ueng SH; Wang MY; Yaw CW; Hou MH* (Jul/Aug 2012) Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching. Analytical Chemistry, 84(15):6391-9 (IF=6.35, Rank=8.33%= 7/84, Chemistry, Analytical)
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Hsu CW; Chuang SM; Wu WL; Hou MH* (Sep 2012) The crucial role of divalent metal ions in the DNA-acting efficacy and inhibition of the transcription of dimeric chromomycin A3. PLOS One, 7(9):e43792 (IF=2.776, Rank=34.7%= 24/69, Multidisciplinary Sciences)
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Chang YM; Chen CK; Hou MH* (Mar 2012) Conformational changes in DNA upon ligand binding monitored by circular dichroism. International Journal of Molecular Sciences,13(3):3394-413 (IF=4.183, Rank=26%= 78/299, Biochemistry & Molecular Biology) (Review)
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Chang YM; Chen CK; Chang YC; Jeng WY; Hou MH; Wang AH* (Sep 2012) Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis. PLOS One, 7(9):e45665 (IF=2.776, Rank=34.7%= 24/69, Multidisciplinary Sciences)
2011-2001
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Kuo SM; Wang CH; Hou MH; Huang YP; Kao HW*; Su HL* (Feb/Aug 2010) Evolution of infectious bronchitis virus in Taiwan: characterisation of RNA recombination in the nucleocapsid gene. Veterinary Microbiology, 144(3-4):293-302.
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Chen IJ; Chou CC; Liu CL; Lee CC; Kan LS; Hou MH* (Jun/Jul 2010) Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid protein. Acta Crystallographica Section F-Structural Biology And Crystallization Communications, 66(Pt 7):815-8.
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Lu WJ; Wang HM; Yuann JM; Huang CY; Hou MH* (Sep/Dec 2009) The impact of spermine competition on the efficacy of DNA-binding Fe (II), Co (II) Complexes of dimeric chromomycin A (3). Journal Of Inorganic Biochemistry, 103(12):1626-33.
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Huang CY; Hsu YL; Chiang WL; Hou MH* (Aug/Nov 2009) Elucidation of the stability and functional regions of the human coronavirus OC43 nucleocapsid protein. Protein Science, 18(11):2209-18.
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Hou MH*, Lu WJ, Huang CY, Fan RJ, Yuann JM (Apr/Jun 2009) Effects of Polyamines on the DNA-Reactive Properties of Dimeric Mithramycin Complexed with Cobalt(II): Implications for Anticancer Therapy. Biochemistry, 48 (22), pp 4691–4698.
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Kuo,CF*; Hou,MH; Wang,TS; Chyau,CC; Chen,YT (Mar/Oct 2009) Enhanced antioxidant activity of Monascus pilosus fermented products by addition of ginger to the medium. FOOD CHEMISTRY. 116,(4);915-922.
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Chou,CC; Hou,MH* (Nov/Dec 2008) Crystallization and preliminary X-ray diffraction analysis of phospholipase A(1) isolated from hornet (Vespa basalis) venom. Acta Crystallographica Section F-Structural Biology And Crystallization Communications. 64(Pt 12):1118-20.
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Hou MH*; Lu WJ; Lin HY; Yuann JM (Apr/May 2008) Studies of sequence-specific DNA binding, DNA cleavage, and topoisomerase inhibition by the dimeric chromomycin A(3) complexed with Fe-II. Biochemistry, 47(20):5493-502.
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Tang TK; Wu MP; Chen ST; Hou MH; Hong MH; Pan FM; Yu HM; Chen JH; Yao CW; Wang AH* (Mar 2005) Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses. Proteomics, 5(4):925-37.
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Hou MH; Wang AH* (Mar 2005) Mithramycin forms a stable dimeric complex by chelating with Fe (II): DNA-interacting characteristics, cellular permeation and cytotoxicity. Nucleic Acids Research, 33(4):1352-61.
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Hou MH; Robinson H; Gao YG; Wang AH (Apr 2004) Crystal structure of the [Mg2+-(chromomycin A(3))(2)]-d(TTGGCCAA)(2) complex reveals GGCC binding specificity of the drug dimer chelated by a metal ion. Nucleic Acids Research, 32(7):2214-22. (Featured on Cover)
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Hou, MH; Robinson H; Gao YG; Wang AH* (Nov 2002) Crystal structure of actinomycin D bound to the CTG triplet repeat sequences linked to neurological diseases. Nucleic Acids Research, 30(22):4910-7. (On cover)
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Hou MH; Lin SB; Yuann JM; Lin WC; Wang AH*; Kan Ls L (Dec 2001) Effects of Polyamines ON the Thermal Stability and formation Kinetics of the DNA duplexes with Abnormal Structure. Nucleic Acids Research, 29(24):5121-8.
2021
2018
會議演講 (Invited speeches)
Month, Year | Title | Conference/Place |
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November 2023 | Targeting protein-protein interaction interfaces with Anti-viral N protein inhibitor in SARS-CoV-2 | In: The 17th International Symposium on Biocatalysis and Agricultural Biotechnology; November 8-10, 2023, National Chung Hsing University, Taichung, Taiwan. |
September 2023 | Research Life Experience Sharing | In: National Sun Yat-Sen University, Kaohsiung, Taiwan (September 15, 2023) |
August 2023 | Synergistic binding of two distinct antibiotic intercalators to mismatch sites and their applications in cancer therapy | In: National Tsing Hua University; Hsinchu, Taiwan (August 31, 2023) |
July 2023 | Targeting trinucleotide repeats using DNA binding small molecules with conformational polymorphism | In: Department of Chemistry, National Taiwan University, Taiwan (July 12, 2023) |
May, 2023 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Lectures of NTHU Chemistry, National Tsing Hua University, Taiwan (May 10, 2023) |
November, 2022 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: 2022 Engineering Bioscience Symposium Challenges & Opportunities in Post-Pandemic Era, National Yang Ming Chiao Tung University, Taiwan (November 18, 2022) |
October, 2022 | Structural Biology in Drug Discovery against Life-threatening Diseases | In: Lectures of Microbiology & Immunology of National Cheng Kung University, Taiwan (October 3, 2022) |
August, 2022 | Targeting mismatches with small molecules induces unusual structural features in disease-related DNA duplexes with therapeutic applications. | In: INDIA-EMBO Lecture Course 2022, RCB Faridabad, India (August 18, 2022, Remote talk) |
June, 2022 | Nucleocapsid capsid protein is a potential target for drug discovery against coronavirus | In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan (June 25, 2022) |
March, 2022 | Structural basis for targeting mismatches with small molecules induces unusual structure features in disease-related DNA duplexes | In: 化學年會2022, National Taiwan Normal University, Taiwan (March 12, 2022) |
December, 2021 | Structural biology in drug discovery against life-threating disease | In: Lectures of NTU Chemistry, National Taiwan University, Taiwan (December 2, 2021) |
December, 2020 | Drug Discovery Platform by Targeting Non-native Protein-Protein Interaction | In: UCDS-NCHU/ENABLE/IDCSA Joint Symposium at National Chung Hsing University Taiwan (December 14, 2020) |
December, 2020 | Structural biology in drug discovery against CoV disease and cancer | In: National Tsing Hua University Taiwan (December 10, 2020) |
November, 2020 | Targeting Non-native Protein–protein Interactions of Nucleocapsid Proteins for Drug Discovery Against Coronavirus | In: The NSRRC 2020 Annual Users’ Meeting & Workshops (November 10, 2020) |
July, 2020 | Development of novel antiviral and anticancer agents: from bench to clinical research | In: 2020 亞洲生技大會BIO Asia - Taiwan (July 23, 2020) |
February, 2019 | Structure-based virtual screening and experimental validation of novel human coronavirus nucleocapsid protein anti-viral inhibitors | In: Structure Assisted Development of Novel Therapeutics 2019; 2019 Feb 12-16. Faridabad, India (February 15, 2019) |
October, 2018 | The action of DNA-binding ligands with unusual DNA structures: implications for therapy and diagnosis of diseases | In: 第十二屆會員代表大會暨2018年全國學術會議; 2018 Oct 25-28. Chongqing, China (October 26, 2018) |
September, 2018 | Recognition of Single-base Mismatch by Echinomycin Raises the Possibility of Repurposing the Drug Against MMR-deficient Cancers | In: 24th Users' Meeting & Workshops, NSRRC; 2018 Sep 11-13. Hsinchu, Taiwan (September 11, 2018) |
July, 2018 | Coronaviral Nucleocapsid Protein is a Potential Target for Drug Development | In: BIT's 7th Annual World Congress of Infectious Diseases (WCID-2018); 2018 July 11-14; Bangkok, Thailand (July 12, 2018) |
May, 2018 | Binding of small molecules to trinucleotide DNA repeats associated with fragile X syndrome | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan. |
研討會論文 (Conference and Seminar poster presentations)
Year | Conference/Seminar name | Authors | Title |
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2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Jia-Rong Tsai, Ming-Hon Hou* | Structural basic and conformational transitions of Actinomycin D-Induced Higher-Order DNA Structures in Mismatched Sequences |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Yen-Yi Lee, Mig-Hon Hou* | Probing the binding mechanism of Actinomycin D and Echinomycin to bulged DNA |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Roshani Bele, Pi-Chung Wang*, Ming-Hon Hou* | Performance improvement of packet classification algorithm by using Decision trees: Implication for biomedical data management |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Jia-Ying Chen, Ming-Hon Hou* | Exploring the therapeutic potential of NA compounds and their application in anti-colorectal cancer strategies |
2023 | In: Nucleic Acids: Prospect and Therapeutic Applications, National Chung Hsing University (July 7, 2023) | Shih-Chun Huang, Ming-Hon Hou* | Symmetric and asymmetric bisacridine derivatives inhibit cancer cell proliferation via binding DNA duplexes |
2023 | In: Chemistry National Meeting, National University of Kaohsiung, Taiwan | Shih-Chun Huang, Ming-Hon Hou* | Structure based study of the binding mechanism of bis-intercalator to DNA duplex |
2023 | In: Chemistry National Meeting, National University of Kaohsiung, Taiwan | Chia-Yu Chen, Ming-Hon Hou* | Structure-based studies of actinomycin D and Z3 molecules targeting Z-DNA
sequence for novel anti-cancer approach |
2023 | In: Chemistry National Meeting, National University of Kaohsiung, Taiwan | Jia-Rong Tsai, Ming-Hon Hou* | Structural-based study of a Four-Way Junction like DNA structure formation
containing a T:T mismatch induced by actinomycin D |
2022 | In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan | Tsai-Hsuan Han, Chih-Chun Chang and Ming-Hon Hou* | The mechanism study of the clinical DNA intercalator- Doxorubicin targeting DNA duplexes for developing potential cancer therapy |
2022 | In: ABA, APPA, TBS Joint Congress 2022, National Cheng Kung University, Taiwan | Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle and Ming-Hon Hou* | Targeting DNA mismatches by two distinct intercalators exhibit synergistic effect against mismatch repair deficient cancers |
2022 | In: Functional Nucleic Acids INDIA-EMBO Lecture Course 2022, Faridabad, Delhi NCR, India | Shun-Ching Wang and Ming-Hon Hou* | Structural basis of Myotonic Dystrophy type 1 CUG repeat RNA crystal reveal multiple water mediated U-U mismatches (online) |
2022 | In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan | Jhen-Yi Hong and Ming-Hon Hou* | Targeting the N-terminus domain of the coronavirus nucleocapsid protein induces abnormal oligomerization via allosteric modulation |
2022 | In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan | Shun-Ching Wang and Ming-Hon Hou* | Structural basis of Myotonic Dystrophy type 1 CUG repeat RNA crystal reveal multiple water mediated U-U mismatches |
2022 | In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan | Shih-Chun Huang and Ming-Hon Hou* | Structure based study of the binding mechanism of bis-intercalator to DNA duplex |
2022 | In: 16th International Symposium on Agricultural Biocatalysis and Biotechnology, Taichung, Taiwan | Roshan Satange, Chih-Chun Chang, Long‐Yuan Li, Sheng-Hao Lin, Stephen Neidle and Ming-Hon Hou* | Targeting DNA mismatches by two distinct intercalators exhibit synergistic effect against mismatch repair deficient cancers |
2021 | In: Chemistry National Meeting,2021, National Central University, Taiwan | Yu-Zhu Huang and Ming-Hon Hou* | Development of triaminotriazine-acridine conjugate (Z1) as a probe to detect cancer-related mismatch in solution |
2019 | In: Structure Assisted Development of Novel Therapeutics 2019; 2019 Feb 12-16. Faridabad, India. | Roshan Satange and Ming-Hon Hou * | Structural heterogeneity in DNA duplex with symmetric G:G mismatches upon CoII(Chromomycin A3)2 and Actinomycin D binding |
2018 | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan | Jing-Yi Zeng, Tzu-Jung Huang and Ming-Hon Hou* | The terminal base pairs determine the conformation of DNA duplex with G:T mismatch. pp.117 (Poster) |
2018 | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan | Ching-Ming Chien, Jia-Ning Hsu and Ming-Hon Hou* | Homology Modeling and Crystallization of N-terminal domain of Porcine Epidemic Diarrhea Virus Nucleocapsid Protein. pp.90 (Poster) |
2018 | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan | Pei-Ching Wu, Shu-Ling Tzeng, Chung-ke Chang, Ya-Fen Kao, Michael J. Waring and Ming-Hon Hou* | Cooperative recognition of T:T mismatch by echinomycin causes structural distortions in DNA duplex. pp.106 (Poster) |
2018 | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan | Hsiang-Ti Huang and Ming-Hon Hou* | Structural basis for the binding of Echinomycin to DNA duplex containing I:C mismatch. pp.91 (Poster) |
2018 | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan | Yun-Jean Lin and Ming-Hon Hou* | Structural study of the specific interactions between echinomycin and methylated DNA containing the CCG motif. pp.103 (Poster) |
2018 | In: The 23rd Biophysics Conference; 2018 May 23-25; Taichung, Taiwan | Roshan Satange and Ming-Hon Hou* | Synergistic intercalation of echinomycin and actinomycin D to DNA duplex with T:T mismatch causes single strand deformation. pp.104 (Poster) |
2017 | In: the 31st Annual Symposium of The Protein Society, 2017 July 24–27, Montreal, Canada. | Hou, MH; Hsu, CN | Structural basis for identification of the interface of the N-terminal domain of CoV N protein dimer as a target for drug development. pp. 196 (Abstract POS501) (Dec 2017) |
2011 | In: 22nd FAOBMB conference | Hsu CW, Chuang SM and Hou MH * | Comparison of DNA-binding properties and anti proliferative effects for chromomycin A3 dimer chelated with various divalent metal ions |
2011 | In: The 36th FEBS congress | Hou MH*, Liu CL, Chen IJ and Chou CC | Identification of the N-terminal domain of human coronaviral nucleocapsid protein as a potential antiviral target |
2012 | In: 17th Joint International Conference of Biophysics and Annual Conference of the Biophysical Society of ROC | Tseng WH, Yuann JM, Lin HY, and Hou MH* | The effects of loop size on Sac7d-hairpin DNA interactions |
2012 | In: Taiwan Society for Biochemistry and Molecular Biology | Chen YW, and Hou MH* | The binding of the Co(II) complex of dimeric chromomycin A3 to GC sites with flanking G:G mismatches |
2012 | In: Taiwan Society for Biochemistry and Molecular Biology | Lin YH, Chen CL, Huang HS, and Hou MH* | The study of anthrax [1, 2-d] imidazole-6,11-dione derivatives bound to the potassium form of human telomere G-quadruplex |
2012 | In: Taiwan Society for Biochemistry and Molecular Biology | Lin SY, Liu CL, Chang YM, and Hou MH* | Probing the N-terminal domain of coronavirus nucleocapsid protein as a potent target for antiviral drug development |
2011 | In: 22nd FAOBMB conference | Liu, CL, Chen, IJ and Hou, MH * | Identification of the N-terminal domain of human coronaviral nucleocapsid protein as a potential antiviral target |
2010 | In: The Taiwan society for biochemistry and molecular biology | Chen, YW and Hou, MH * | Probing the interaction of the residue Y148 in influenza A virus nucleoprotein involved in RNA-binding |
2010 | In: 4th Asian Bioinorganic Chemistry Conference | Hou, MH *, Lu, WJ, Wang, HM, Yuann, JM, and Huang, CY | The Impact of spermine Competition ON The efficacy of the DNA-Binding of Fe (II), of Co (II), and a Cu (II ) Complexes of dimeric chromomycin A (3) |
2010 | In: 24th International Conference on Organometallic Chemistry | Hou, MH*, Lu, WJ, Huang, CY, Fan, the RJ, and Yuann, JM | Effects of Polyamines on the DNA-reactive Properties of dimeric Mithramycin complexed with Cobalt (II): Implications for Anticancer Therapy |
2010 | In: The Taiwan society for biochemistry and molecular biology | Lo, YS, Chiu, YL and Hou, MH * | The crucial role of C-terminal tail of human coronavirus 229E nucleocapsid protein in oligomerization |
2009 | In: 14th Joint International Conference of Biophysics and Annual Conference of the Biophysical Society of ROC | Chiang, CH, Wu, FC and Hou, MH * | Probing the necessary residues of influenza virus (H1N1) nucleocapsid for RNA-binding |
2009 | In: 14th Joint International Conference of Biophysics and Annual Conference of the Biophysical Society of ROC | Chiu, YL, Lo, YS and Hou, MH* | Characterization of the C-terminal domain of human coronavirus 229E nucleocapsid protein in RNA-binding and oligomerization |
2009 | In: VIII European Symposium of The Protein Society | Hou MH*, Chiang CH, Wu FC and Lo YS | Probing the necessary residues of influenza virus (H1N1) nucleoprotein for RNA-binding |
2008 | In: 23th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan | Liang FY, Lin TJ, Hsu YL, Ying TH and Hou MH* | Prokaryotic expression and antigenicity analysis of human coronavirus OC43 nucleocapsid protein. |
2008 | In: The 22nd Symposium of The Protein Society 2008 | Hou, MH* and Huang, CY | Functional domains identification of human coronavirus 229E nucleocapsid protein (Abstract) |
2007 | In: Experimental Biology Annual Meeting 2007 | Hou, MH*, Hsu, YL, Huang, CY and Chiang, WL | Characterization of human coronavirus OC43 nucleocapsid protein (Abstract) |
2007 | In: The 21st Symposium of The Protein Society 2007 | Hou, MH* and Huang, CY, | The Studies of Biochemical Properties and Stability of Recombinant Human Coronavirus OC43 Nucleocapsid Protein (Abstract) |
2005 | In: 13th Symposium on Recent Advances in Cellular and Molecular Biology | Hou, MH, Robinson H, Gao YG and Wang AH-J. | The interference mechanism of actinomycin D bound to CTG triplet repeat associated with myotonic dystrophy (Abstract) |
2004 | In: 21th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan | Hou, MH, Hsu, YL, Tang, TK, Yao, CW, and Wang, AH-J. | Biochemical and Stability s of Recombinant Human coronavirus OC43 nucleocapsid Protein (Abstract) |
2004 | In: 21th Joint Annual Conference of Biomedical Sciences, Taipei, Taiwan | Hou, MH, Lin, HY, Lu, WJ, Kan, LS, and Wang, AH-J | DNA-Binding Characterization of The dimeric chromomycin A3 Complex chelated with of Fe (II) Ion: Sequence by the preference, the DNA cleavage and topoisomerase the I Inhibition (Abstract) |
2003 | In: 4th East Asian Biophysics Symposium | Hou, MH, Robinson H., Gao YG and Wang AH-J. | The Crystal Structure of The of Mg2 + -.. (Chromomycin A3) 2-D (TTGGCCAA) 2 Complex reveals GGCC Binding specificity of The Drug dimer chelated by Metal Ion (Abstract) |
2002 | In: The 8th Symposium on Recent Advances in Biophysics | Hou, MH, Robinson H., Gao YG and Wang AH-J. | Crystal structure of actinomycin D bound to the CTG triplet transition series linked to neurological diseases (Abstract) |
1999 | In: The 5th Symposium on Recent Advances in Biophysics | Hou, MH, Kan LS and Lin SB | The kinetic study of the effect of polyamine on the formation of AT base pair-rich DNA duplexes by surface plasmon resonance (Abstract) |
1998 | In: The 4th Symposium on Recent Advances in Biophysics | Hou, MH, Kan LS and Lin SB | Stability of DNA duplex re-visit: The effect of polyamine (Abstract) |